Papules on the arms and legs if rough are usually warts and if smoothe consider granuloma annulare.If there is a bit of superficial spreading scale think of tinea corporis.Lichenified eczema on the anterior shins is often papular but other itchy papular disorders such as lichen amyloidosis and hypertrophic lichen planus should also be considered..In white populations sun damage will cause basal and squamous cell skin cancers and rarely colloid milium.
If the papules are tiny think of lichen nitidus.If they are on the wrist or dorsum of the foot and ankle and purplish think of lichen planus.Papules on the palms may be secondary syphilis.Lichen striatus and epidermal nevi commonly involve the arms and legs may do so in a linear fashion.Papular mucinosis is seen more commonly on the extensor forearms and acrokeratosis verruciformis may involve the ankles..Erythema multiforme will give characteristic iris lesions on the lower legs.
Very rare conditions such as multicentric reticulohistiocytosis can present as hand papules.
Management If you are not sure biopsy it.
SIGN DIP MEN Overview of Papules
This is an extremely difficult area to give an all encompassing nemonic but SIGN DIP LAPPIS can be used where L=Lichen etc,A=Adnexae,P=Pediculosis,P=Perforating diseases,I=Infiltrates xanthoma etc,and S=Syndromes Grover’s,Darier’s, Albopapuloid EB etc
It is probably best to view the differential diagnosis of papules in particular situations
Monomorphic micropapules in a group Lichen nitidus,keratosis spinulosa,follicular eczema,follicular mucinosis,lichen scrofulosorum,sarcoidosis,lichen planus,keratosis pilaris
Polymorphic papules with necrosis Pityriasis lichenoides ,lymphomatoid papulosis,papulonecrotic tuberculid,Wegener’s granuloma,allergic granulomatosis,leukocytoclastic vasculitis,insect bites,acne necrotica,acnitis.
Keratotic papules forming rings or arciform lesions porokeratoses,perforating collagenoses,Kyrles disease,Elastosis perforans serpiginosa
Inflammatory papular dermatitis in children Gianoti Crosti syndrome,Papular acral located syndrome,papular urticaria,frictional dermatitis,Bindii dermatitis,caterpillar hairs,mite bites,benign cephalic histiocytosis
Facial adnexal papules Syringoma,trichoepithelioma,adenoma sebaceum,benighn cephalic histiocytosis,Cowden’s syndrome
Eyelid Papules Milia,molluscum contagiosum,xanthoma,xanthogranuoma,amyloid,trichoepithelioma,Syringomas,acnitis,Cowden’s,Lipoid proteinosis,papular mucinosis
Multiple papules in the mouth Cowdens,Darier’s,Goltz,florid oral papillomatosis,xanthoma disseminatum,reticulo histiocytosis,lipoid proteinosis,adenoma sebaceum,drugs,pyostomatitis vegetans,verrucous carcinoma
Acral papules warts,Gianotti-Crosti,Cowden’s,Multicentric reticulohistiocytosis,epidermodysplasia verruciformis,viral infection
Follicular Papules Keratosis pilaris,lichen spinulosus,lichen planopilaris,Pityriasis rubra pilaris,lichen sclerosus,follicular mucinosis,discoid lupus erythematosus,vitamin d deficiency,fatty acid deficiency
SIGN DIP NIGL
N Nutritional Vit A,Vit C,essential fatty acid deficiency
I Infiltrates
G Genodermatoses Darier’s,Downs,Kyrles.
L Lichenoid
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